AFFiRiS GmbH: Milestone Reached In Clinical Trial Of Alzheimer's Vaccine

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The developmental no-effect dose in these studies was 10В mg/kg/day in both rats and rabbits (maternal exposures approximately 15 times human exposure at the MRDD).
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The use of antispasmodic drugs is not encouraged as the therapeutic benefit over placebo is hardly proven.
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Accumulation and slow elimination — The relatively slow elimination of fluoxetine (elimination half–life of 1 to 3 days after acute administration and 4 to 6 days after chronic administration) and its active metabolite, norfluoxetine (elimination half–life of 4 to 16 days after acute and chronic administration), leads to significant accumulation of these active species in chronic use and delayed attainment of steady state, even when a fixed dose is used.
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The mechanism(s) which predispose patients to the development of this complication has not been identified.
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Fluoxetine was also significantly more effective than placebo on the HAM-D subscores for depressed mood, sleep disturbance, and the anxiety subfactor.
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For stress-induced headache various forms of stress reduction can be helpful as can biofeedback and meditation.
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Repletion of central fluid volume (Trendelenburg positioning, infusion of crystalloids) may be sufficient therapy, but pressor agents (norepinephrine or high-dose dopamine) may be required.
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The headquarters are in Geneva, Switzerland.

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In the absence of metabolic activation, neither spironolactone nor potassium canrenoate has been shown to be mutagenic in mammalian tests in vitro.
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NIDCD-supported scientists are studying the tiny fly Ormia ochracea because its ear structure allows the fly to determine the source of a sound easily.
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Procedures should be implemented to avoid administration errors and viral contamination of personnel during blood product labeling.
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Poisoning OverviewIf you or someone you know has swallowed or breathed in a poison, and you or they have serious signs or symptoms (nausea, vomiting, pain, trouble breathing, seizure, confusion, or abnormal skin color), then you must either call an ambulance for transport to a hospital emergency department or call a poison control center for guidance.

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Therefore, animal studies to evaluate carcinogenic potential with AZELEXВ® Cream were not deemed necessary.
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The cancer is more prevalent in people with compromised immune systems, such as people with acquired immune deficiency syndrome (AIDS).
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Surgical menopause: Surgical menopause is menopause induced by the removal of the ovaries.
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Photosensitivity, manifested by an exaggerated sunburn reaction, has been observed in some individuals taking tetracyclines.
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Overall though, note that the benefits of ANY yoga practice on someone who suffers from IBD would far outweigh the risks.
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When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy).
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Photodynamic therapy causes little damage to healthy tissue.
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Other adolescents who want to decrease their risk of meningococcal disease can also get the vaccine.
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Adequate and well-controlled studies in pregnant women have not been conducted.
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The large majority of patients experience substantial improvement when treated with antipsychotic agents.
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Although opinions on this may vary, most yogis would probably agree that there is nothing inherently religious about most yoga techniques.
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Symptoms of porencephaly include delayed growth and development, spastic hemiplegia (slight or incomplete paralysis), hypotonia (low muscle tone), seizures (often infantile spasms), and macrocephaly (large head) or microcephaly (small head).
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The rate of symptomatic intracerebral hemorrhage (6.3%) in IMS subjects was similar to that of rtPA-treated subjects (6.6%) but higher than the rate in placebo-treated subjects (1.0%; P=0.018) in the NINDS rtPA Stroke Trial.
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This type of pericarditis can present with swelling (edema) of the feet, ankles and legs.

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The structures that help provide stability to the knee are the bones of the leg and thigh, cartilage, muscles, ligaments, and tendons.
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Three genes that promote familial hemiplegic migraine have now been identified, each affecting a subunit of a different ion channel.
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Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation.
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Injection is made into a biliary duct by the percutaneous transhepatic method.
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The diagnostic evaluation of patients with this syndrome is complicated.
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Patients requiring sulfasalazine should follow up with their physicians to determine the need for continued administration.
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The formula and an example of the method for someone 27 years old, assuming a resting heart rate of 70 beats per minute (bpm), and a training range of 70%, may be found below.

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Expectoration is expected to decrease the amount of radioactive contaminant available for systemic absorption.
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Although a diagnosis usually can be made without a CT scan, the technique may be useful in determining the extent of bone damage.
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IN THIS ARTICLECostochondritis OverviewCostochondritis CausesCostochondritis SymptomsWhen to Seek Medical CareExams and TestsCostochondritis TreatmentSelf-Care at HomeMedicationsSurgeryNext StepsFollow-upPreventionOutlookSynonyms and KeywordsAuthors and EditorsNext StepsFollow-upYou should see a doctor during recovery, and then once a year.
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Concomitant administration of CUBICIN (6 mg/kg q24h for 5 days) and warfarin (25 mg single oral dose) had no significant effect on the pharmacokinetics of either drug, and the INR was not significantly altered.
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The conus is the part that will be inferior to the aortic and pulmonary valves, and the truncus is the part superior to the valves that is continuous with the ventral aorta (aortic sac).
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Information about ongoing clinical trials is available from the NCI Web site.
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The choice of medication depends upon the type of infection.
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Over half of the patients responding to CAMPTOSAR had not responded to prior 5-FU.
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Non–Small-Cell Lung Cancer OverviewCancers are diseases in which normal cells transform so that they grow and multiply without normal controls.
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The new data support the previous phase I study[646] and single-center case series[647] supporting the safety of this approach.
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In patients with severe renal impairment or who were hemodialysis dependent, Cmax and AUC values increased by approximately 1.7- and 2.5-fold, respectively.
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Large blisters can run together, and large sheets of skin peel from the body.
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The disease may also be hereditary, as between 2% and 5% of cases have family members with the disease.

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Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
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Although inhibition of ADP-induced platelet aggregation was lower (25%) than that observed in healthy volunteers, the prolongation of bleeding time was similar to healthy volunteers receiving 75 mg of clopidogrel bisulfate per day.
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For women who have a uterus, adequate diagnostic measures, such as endometrial sampling, when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.
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Severe infection or disease complications occur more commonly in infants.
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Pain will be addressed and managed effectively.
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The guideline underwent extensive peer review before consideration and approval by the AHA Science Advisory and Coordinating Committee.
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The mucus builds up in your lungs and blocks the airways.
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A major cause of adverse reactions to this group of drugs is excessive plasma levels, which may be due to overdosage, inadvertent intravascular injection, or slow metabolic degradation.
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However, another patient who took 2.5 grams of sertraline hydrochloride alone experienced a fatal outcome.
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Making new bone involves the coordinated actions of cells called osteoclasts and osteoblasts.

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Oral blisters are treated with mouthwashes and rinses with numbing medicine for pain relief.
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People with peripheral edema, or swelling in the legs, from heart failure, liver conditions and other conditions may benefit from wearing skin compression stockings to help prevent skin breakdown and the erysipelas that may result.
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Ceftazidime and the aminoglycosides have been shown to be synergistic in vitro against Pseudomonas aeruginosa and the enterobacteriaceae.
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Here, dermatophytes invade and digest the tissue's keratin (a type of protein) as the organisms grow.
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Occasionally, patients may experience cough and/or bronchospasm following inhalation of cromolyn sodium.
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It is recommended that a urinalysis should be obtained prior to each dose of IFEX.
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For the same period, about 40–45% of the administered radioactivity was accounted for in feces, including 12–14% unchanged sertraline.
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Substances made by the body or made in a laboratory are used to boost, direct, or restore the body's natural defenses against cancer.
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Side effects of propranolol are bronchospasm (this cannot be used in persons with asthma), sleepiness, andimpotence, among others.
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In man, peripheral vasodilation produced by immediate-release DynaCircВ® (isradipine) is reflected by decreased systemic vascular resistance and increased cardiac output.

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Some users may experience slight deterioration in glucose tolerance, with increases in plasma insulin but women with diabetes mellitus who use progestin-only oral contraceptives do not generally experience changes in their insulin requirements.
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The use of pergolide in patients on l-dopa may cause and/or exacerbate preexisting states of confusion and hallucinations (see[#section-7 WARNINGS]) and preexisting dyskinesia.
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Desonide Ointment contains desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16, 17-[(1-methylethylidene)bis(oxy)]-, (11ОІ,16 О±)) a synthetic corticosteroid for topical dermatologic use.
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IN THIS ARTICLEHeartburn FAQs IntroductionWhy does the acid back up into the esophagus?Do spicy foods cause heartburn?Why do I always get heartburn at night?Sometimes I get a sour taste in my mouth when I bend over--what is that?How common is heartburn?Is heartburn a serious condition?What kinds of complications are caused by frequent heartburn?If I have heartburn, should I see my health care provider?Aren't there any tests for heartburn?What is the treatment for heartburn?What are my options if these treatments don't work?When is surgery needed for heartburn?How can I prevent heartburn?What happens if I stop treatment?For More InformationWeb LinksMultimediaSynonyms and KeywordsAuthors and EditorsWhat are my options if these treatments don't work?If you continue to have heartburn, your health care provider may recommend adding a drug such as metoclopramide (Reglan).
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Curcumin also has a number of other biological effects in the body.
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Viruses cause about 90% of sore throats and are a much more common cause than strep.
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It is only diagnosed when symptoms are so bad that they make it hard for a woman to function normally.
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These tumors were common in control groups as well as treated groups and the difference became apparent only in aged rats.
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Theophylline does not undergo any appreciable pre-systemic elimination, distributes freely into fat-free tissues and is extensively metabolized in the liver.

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After appropriate treatment and surgery, however, results have been good.
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The recommended initial dosage of LONITEN Tablets is 5 mg of minoxidil given as a single daily dose.
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The patient should be observed and appropriate hydration maintained.
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Treatment choices depend on the problem and the person’s preference, However, it is important to note that research tends to to support more enduring positive outcomes, particularly for conditions like social phobia, when appropriate evidence-based psychotherapeutic approaches are employed.
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The nasopharynx is the upper part of the pharynx (throat) behind the nose.
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The onset of this syndrome may be heralded by flank pain and hematuria.
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Amyotrophic lateral sclerosis, also known as Lou Gehrig disease or classical motor neuron disease, is a progressive, ultimately fatal disorder that eventually disrupts signals to all voluntary muscles.
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IN THIS ARTICLEIntroduction: History of Food and Drug RegulationFDA Mission and BackgroundProduct Approvals (Drugs and Food)Food LabelsFood SafetyDietary Supplements, Infant Formulas, CosmeticsEnforcement of the FD&C ActFDA ChallengesFor More InformationSynonyms and KeywordsAuthors and EditorsFDA ChallengesThe FDA faces a number of important challenges in its efforts to ensure a safe food and drug supply.
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PREVACID NapraPAC 500 is a combination package containing NAPROSYN 500 mg tablets and PREVACID 15 mg capsules.
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Chemotherapy uses drugs to kill cancer cells.

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Creams and ointments work better at healing the skin.
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Among 633 adult patients who overdosed on fluoxetine hydrochloride alone, 34 resulted in a fatal outcome, 378 completely recovered, and 15 patients experienced sequelae after overdosage, including abnormal accommodation, abnormal gait, confusion, unresponsiveness, nervousness, pulmonary dysfunction, vertigo, tremor, elevated blood pressure, impotence, movement disorder, and hypomania.
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Early vertebrate embryos composed of about 100 to 1000 cells are sometimes called blastulae.
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It is often, though not always, possible to diagnose OI based solely on clinical features.
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These tests involve having you breathe into a tube that is connected to a computer or some other monitoring device, which can record the necessary information.
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S. typhimurium causes a disease called typhoid fever.
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Capillary leak syndrome or SIRS (signs and symptoms of cytokine release, e.g., tachypnea, tachycardia, hypotension, pulmonary edema), occurred in 4 pediatric patients overall (3 ALL, 1 AML).
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This damage can be drastic and eventually precipitate failure of organ systems such as the lungs, kidneys or the nervous system.

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Breast milk obtained over eight hours post-dose revealed that the maximum concentration of budesonide for the 400 and 800 mcg doses was 0.39 and 0.78 nmol/L, respectively, and occurred within 45 minutes after dosing.
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The process of rebuilding (reconstructing) a part of the body changed by previous surgery is called reconstructive surgery.
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Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
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Using a scale of 1 to 10, the images were evaluated by the blinded readers for the level of conspicuity of all lesions, the ability to delineate lesion borders from parenchyma/structures, the number of lesions and confidence in the number of lesions.
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In the 1300s, the "Black Death," as it was called, killed approximately one-third (20 to 30 million) of Europe's population.
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Hypertension is also known as high blood pressure.
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If appropriate, angiotensin converting enzyme (ACE) inhibitors and beta blocker medications may be used to allow the heart to beat more efficiently, potentially increasing cardiac output.