Repligen Receives Orphan Drug Designation From The FDA For RG1068 For MRI Imaging Of The Pancreas

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These medications may be taken by mouth (orally), but they are usually injected into a vein (IV).
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The percent of patients whose blood was sterilized as shown by one or more negative cultures at any time during acute therapy was 61% (30/49) for the 500 mg b.i.d. group and 59% (29/49) and 52% (25/48) for the 1000 and 2000 mg b.i.d. groups, respectively.
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In one case, the patient abruptly discontinued XANAX XR, and in both cases, alcohol intake was implicated.
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There has been no systematic evaluation of morphine sulfate extended-release tablets as an initial opioid analgesic in the management of pain.

The common risk factors are smoking and poor control of high blood pressure, high cholesterol levels, and diabetes.
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Earlier studies have reported an increased lifetime relative risk of gallbladder surgery in users of oral contraceptives and estrogens.
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Sciatica is pain resulting from irritation of the sciatic nerve.

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Read circulars for lithium preparations before use of such concomitant therapy.
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Over the years, roseola has had several different names including roseola infantum, roseola infantilis, and exanthem subitum.
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HIV from therapy-naive subjects with no mutations associated with resistance gave median EC50 values of 0.426В ВµM (range: 0.200 to 2.007В ВµM) from Virco (nВ =В 93 baseline samples from COLA40263) and 2.35В ВµM (1.44 to 4.08В ВµM) from Monogram Biosciences (nВ =В 135 baseline samples from ESS30009). The EC50 values of lamivudine against different HIV-1 clades (A-G) ranged from 0.001 to 0.120В ВµM, and against HIV-2 isolates from 0.003 to 0.120В ОјM in peripheral blood mononuclear cells.
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In patients with subarachnoid hemorrhage, a rare association between contrast administration and clinical deterioration, including convulsions and death, has been reported.
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Saquinavir is a peptide-like substrate analogue that binds to the protease active site and inhibits the activity of the enzyme.

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GI anthrax begins with nonspecific symptoms of nausea, vomiting, and fever.
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Extrinsic and intrinsic causes of cardiomyopathies are discussed below.
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The only example now in widespread use is alpha-tocopherol, or vitamin E (Vita-Plus E Softgels, Vitec, Aquasol E).
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In these populations, relative to adults, the pharmacokinetics of SSZ and SP correlated poorly with either age or dose.
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A dental abscess is an infection of the mouth, face, jaw, or throat that begins as a tooth infection or cavity.
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However, there continues to be controversy about the extent to which such findings may be due to differences in sexual behavior and other factors.
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Once absorbed, adefovir dipivoxil is rapidly broken down to adefovir by extracellular enzymes called esterases.

Worldwide initiatives to increase access to clean water and adequate hygiene is perhaps the most important way to save lives.
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If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
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When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy).

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Within a few months after receiving an IOL, the patient will become used to improved color vision.
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Peak concentrations of 198 ng/mL were obtained at 1 hour after a 60 mg dose.
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Treatment is symptomatic and may include medication therapies with nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids to reduce swelling, as well as antibiotics and immunosuppressants.
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IN THIS ARTICLEPustular Psoriasis OverviewPustular Psoriasis CausesPustular Psoriasis SymptomsWhen to Seek Medical CareExams and TestsPustular Psoriasis TreatmentMedical TreatmentMedicationsOther TherapyNext StepsPreventionOutlookSupport Groups and CounselingFor More InformationWeb LinksMultimediaSynonyms and KeywordsAuthors and EditorsOther TherapyConventional therapy has been tested with clinical trials.

Anytime a muscle is torn, the body repairs itself by forming scar tissue.
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All patients with a CLcr less than 22 mL/min had adequate control of their glucose levels with a dosage regimen of only 1 mg daily.

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In normal volunteers, ZEBETA therapy resulted in a reduction of exercise- and isoproterenol-induced tachycardia.
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The "ball," or humerus, is the top, rounded portion of the upper arm bone; the "socket," or glenoid, is a dish-shaped part of the outer edge of the scapula into which the ball fits.
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Pharmacokinetic data following single and repeat oral doses show that dutasteride has a large volume of distribution (300 to 500В L).
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Two 6 week controlled studies (N = 671, randomized) comparing fluoxetine 20 mg, and placebo have shown fluoxetine 20 mg daily, to be effective in the treatment of elderly patients (≥ 60 years of age) with major depressive disorder.

This can happen to older children with severe damage to the nervous system, children with a life-threatening bacterial infection in the blood (sepsis), and children with a weakened immune system.
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If your child has thrombocytopenia, try to protect him or her from injuries, especially head injuries that can cause bleeding in the brain.
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The doctor will also ask if you have a family history of osteoporosis or a history of previous broken bones.

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What does the BMI mean? Healthy BMI = 18.5-24.9 Overweight = 25.0-29.9 Obese = 30 or greater Morbidly obese = 40 or greaterTo calculate your body mass index on the internet, fill in your height and weight at the Web site of the United States government's National Heart, Lung, and Blood Institute's Obesity Education Initiative.
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Breathing retraining techniques (eg, diaphragmatic, pursed lip breathing) may improve your breathing pattern and prevent airway compression.
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Septo-optic dysplasia (SOD) is a rare disorder characterized by abnormal development of the optic disk, pituitary deficiencies, and often agenesis (absence) of the septum pellucidum (the part of the brain that separates the anterior horns or the lateral ventricles of the brain).
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PrevaliteВ® is contraindicated in patients with complete biliary obstruction where bile is not secreted into the intestine and in those individuals who have shown hypersensitivity to any of its components.
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In fertility studies in rats, males were given epirubicin daily for 9 weeks and mated with females that were given epirubicin daily for 2 weeks prior to mating and through Day 7 of gestation.
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All other pharmacokinetic parameter values (t1/2, Vd, and CL) are similar to those observed with intravenous ranitidine use in pediatric patients.
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The role of genetics in risk stratification and in the responsiveness to preventive interventions is an active and important area of research.
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Typically, gynecomastia is not associated with long-term problems, but men with gynecomastia have an increased risk (about five-fold) for developing male breast cancer when compared with the general population.
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Hepatitis A, known simply as infectious hepatitis before the diversity of hepatitis-causing viruses was described, has been known since antiquity and probably caused epidemics of "campaign jaundice" among armies of the Middle Ages.

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These reactions are listed in approximate decreasing order of occurrence: dryness, folliculitis, acneiform eruptions, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, miliaria, burning and hypopigmentation.
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Ampicillin class antibiotics are excreted in the milk; therefore, caution should be exercised when amoxicillin and clavulanate potassium for oral suspension and chewable tablets are administered to a nursing woman.
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Peak circulating levels of rosuvastatin are reached 3–5 hours post-dosing.
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Use of bromocriptine, another dopamine agonist for this purpose, has been associated with cases of hypertension, stroke, and seizures.
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Laryngospasm, shock, and cardiopulmonary arrest have occurred during allergic reactions in patients receiving injectable ondansetron.
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Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.

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These adverse events and adverse events from the Phase 3 second-line ovarian carcinoma study are described in the ADVERSE REACTIONS section in tabular (Tables 4 & 5) and narrative form.
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The effect of long-term use of the oral contraceptives with lower formulations of both estrogens and progestogens remains to be determined.
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Gender Gender differences in theophylline clearance are relatively small and unlikely to be of clinical significance.
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This mutation, on one of the X chromosomes, was found in nearly 15 percent of women who had a history of repeated, unexplained miscarriage.
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Prednisolone Acetate Ophthalmic Suspension USP, 1% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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This genus includes many other species of bacteria associated with human disease, including those in the spotted fever group and in the typhus group.

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After 4 weeks, effects on heart rate, plasma glucose, and plasma potassium were generally diminished compared with day 1 in all active treatment groups.
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Abnormal lung or heart sounds could also signify sarcoidosis.
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Once a health care practitioner has confirmed an individual has dandruff (seborrheic dermatitis), the main treatment includes antifungal shampoos, antibacterial cleansers, and anti-inflammatory creams and lotions.
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These partners should be advised to seek medical attention if they develop any signs of the illness.
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It can be exacerbated or seen more often in patients who are pregnant, have diabetes, are dehydrated, or taking high blood pressure medications.
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Geriatric Use: In studies where geriatric patients (65 years of age or older, see [#section-7 PRECAUTIONS]) have been treated with Temovate EВ® Emollient, safety did not differ from that in younger patients, therefore no dosage adjustment is recommended.

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Good control of diabetes is especially important for you and your unborn baby.
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Many of these are preventable by maintaining a healthy lifestyle and controlling illnesses like hypertension and diabetes.
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This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation.
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There have been rare reports of altered platelet function and/or abnormal results from laboratory studies in patients taking ZOLOFT.
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All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.
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There are no adequate and well-controlled studies of systemic acyclovir in pregnant women.
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Interpretation involves correlation of the diameters obtained in the disk test with the minimum inhibitory concentration (MIC) for tobramycin.
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The patient (or parent/care giver) should be instructed to seek medical advice whenever nausea, vomiting, persistent headache, insomnia or rapid heart beat occurs during treatment with theophylline, even if another cause is suspected.
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However, trauma from a fishhook piercing the skin is common.

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Whether these interventions help is unknown.
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Another well-controlled clinical study evaluated 279 subjects with mild to moderate plaque-type psoriasis (mean Body Surface Area at baseline was 6.7% with a range from 1% to 20%) of non-scalp regions.
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Practitioners are challenged to sortout what is true risk and benefit, and what is marketing strategy, in a burgeoning “bone health”industry.
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This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied.
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Blood tests may be ordered to help rule out other conditions that may mimic PMDD.
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Extensive epidemiological studies have revealed no increased risk of birth defects in women who have used oral contraceptives prior to pregnancy.
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Echocardiography also can be performed through the esophagus (the tube leading from the mouth to the stomach) to get a closer look at the mitral valve.
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Other problems associated with indwelling urethral catheters include encrustation of the catheter, bladder spasms resulting in urinary leakage, blood in the urine (hematuria), and inflammation of the urethra (urethritis).
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This alkylation damages the integrity of a cell's DNA, which leads to cell death.

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Gastric lavage may be useful, and activated charcoal can adsorb a significant amount of ingested propoxyphene.
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This dose should be reached after 4 to 6 weeks of incremental dosage increases as stated above.
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Daily vitamin E can reduce fibrocystic changes.
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CDAD must be considered in all patients who present with diarrhea following antibiotic use.
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This means that the pregnancy is not in the uterus.
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When associated symptoms such as attention deficit hyperactivity disorder, depression, or aggression occur, it is important to receive appropriate support services which include counseling to reduce stress and anxiety, as well as mental health services.
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No data are available concerning the potential for carcinogenicity or mutagenicity in animals or humans.
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Fluticasone propionate is a white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.
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Any change of insulin should be made cautiously and only under medical supervision.

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Eventually, the person with PD and dementia will become unable to care for himself or herself or even to make decisions about his or her care.
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Status Epilepticus: In the three double-blind, placebo-controlled, parallel-group studies (Studies 1, 2, and 3), the incidence of any type of status epilepticus (simple, complex, or generalized tonic-clonic) in patients receiving GABITRIL was 0.8% (4 of 494 patients) versus 0.7% (2 of 275 patients) receiving placebo.
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This is called a pleural effusion.
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Treatment includes dietary changes, insulin, oral medications, and, in severe cases, a feeding tube and parenteral nutrition.
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Overdosage has the potential to have harmful cardiovascular consequences, such as high blood pressure or more serious cardiovascular events.
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For each subject, a growth rate was defined as the slope of a linear regression line fit to the height measurements over 56 weeks.
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For details of technique and placement sites, consult the medical literature.
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The remainder of the waves are anovulatory, characterized by the developed preovulatory follicle falling into atresia (a major anovulatory cycle) or no preovulatory follicle being chosen at all (a minor anovulatory cycle).
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The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

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In addition, CDC conducts investigations of outbreaks of yersiniosis to control them and to learn more about how to prevent these infections.
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Body as a Whole — Frequent: chills, infection, neck pain, neck rigidity, photosensitivity reaction; Infrequent: cellulitis, cyst, hernia, intentional injury, intentional overdose, malaise, moniliasis, overdose, pelvic pain, suicide attempt; Rare: death, tolerance decreased.
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Your symptoms may go away before the infection is cured and you may feel much better, but finish taking all the antibiotics prescribed for you.
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Keep the wound clean and remove any hair from around the site to prevent recurrence.
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PSE-301 was a randomized, multicenter, open-label study designed to evaluate the safety and efficacy of SeasoniqueTM for approximately 1 year (four 91-day SeasoniqueTM extended cycles).
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The goal is to relieve pressure on the nerves of the cauda equina by removing the compressing structures and increasing the space available for the nerves in the spinal canal.
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Note the time the tourniquet was applied and remove as soon as possible.
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Only 0.1% of the dose is excreted in the urine as unchanged drug.
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Consequently, for adults, clear fluids (for example, sports drinks, Sprite, juices without any pulp, bouillon) are recommended.

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External Insulin Pumps — Humalog was tested in MiniMed®1 Models 506, 507, and 508 insulin pumps using MiniMed®1 Polyfin®1 infusion sets.
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As with the use of fluoxetine in the treatment of major depressive disorder, a lower or less frequent dosage should be used in patients with hepatic impairment.
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Smoking: If the patient has diabetes, and you smoke cigarettes or use any other form of tobacco, they are raising the risks markedly for nearly all of the complications of diabetes.
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The low rate of complete recanalization and the high rate of reocclusion with stroke thrombolysis is not surprising when it is considered that not even aspirin is allowed for 24 hours after intravenous rtPA.
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If a vasoconstrictor is required, norepinephrine bitartrate and phenylephrine hydrochloride are suitable.
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Turner syndrome is a condition caused by monosomy.
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They contain a Foley catheter, water-soluble lubricant jelly, a 10cc syringe with sterile water for the Foley balloon, a sterile drainage bag with sample port and tubing, sterile drapes, sterile gloves, iodine, sterile gauze, sterile specimen cup, and forceps.
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About 15% of patients in long-term studies converted to a positive titer, although about one-third of these patients subsequently reconverted to a negative titer while on continued therapy.
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Single-dose treatment is available, but is not recommended for some groups of patients, for example, those who have delayed treatment or have signs of a kidney infection, patients with diabetes or structural abnormalities, or men who have prostate infections.