Repligen Receives Orphan Drug Designation From The FDA For RG1068 For MRI Imaging Of The Pancreas

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Myasthenia gravis can be controlled.
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Smoking: Smoking any form of tobacco causes damage to the small blood vessels in the feet and legs.
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The potential effects of fentanyl on male and female fertility were examined in the rat model via two separate experiments.
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Acrodynia (rash, fever, irritability, splenomegaly, and muscle weakness) can be seen in patients, especially children, exposed to most forms of mercury poisoning.
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With all of these procedures, either laser or cryopexy is used to "weld" the retina back in place.
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Tendinitis is an inflammation of the tendon.
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The National Institute of Neurological Disorders and Stroke (NINDS) conducts TBI research in its laboratories at the National Institutes of Health (NIH) and also supports TBI research through grants to major medical institutions across the country.
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Soft tissue injuries and amputations Apply pressure to stop bleeding.
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This process repeats with each new heartbeat.

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They may allow you to carry on with your normal activities more easily than older first-generation antihistamines.
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While it is true that the 60-minute values are usually higher than the 30-minute values, the difference may not be significant enough in most cases to outweigh the disadvantage of a longer testing period.
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Goldenseal is considered safe for short-term use in adults at recommended dosages.
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Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
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Most patients are diagnosed with stage I disease.
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This risk is present whether the drugs are administered as oral, parenteral, or topical formulations.
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CDAD must be considered in all patients who present with diarrhea following antibiotic use.

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Single oral doses of ursodiol at 10, 5 and 10 g/kg in mice, rats and dogs, respectively, were not lethal.
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Men who have had testicular cancer should see their doctor regularly and should report any unusual symptoms right away.
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More than half of these children also have inflammation in variable segments of the colon.
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Transmision of a signal along the length of a neuron's elongated axons is electrical, while that bewteen different neurons is via neurotransmiter chemical transfer.
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People often decide to seek care after an injury based upon their ability to stand, bear weight, and walk.
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Several reproduction studies have been performed in rabbits and rats at doses up to six times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to nitrofurantoin.
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These factors include genetics (heredity), hormones (explaining why the disease is more common in women than men), and possibly infection by a bacterium or virus.
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If the diagnosis is uncertain or a cutaneous malignancy is suspected, the dermatologic surgeon may perform a small punch biopsy (using a local anesthetic) for examination under the microscope by the dermatologist who is a trained dermatopathologist.
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We have two copies of each gene, except for the genes on the sex chromosomes.

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The MAOIs most commonly prescribed for anxiety disorders are phenelzine (Nardil), followed by tranylcypromine (Parnate), and isocarboxazid (Marplan), which are useful in treating panic disorder and social phobia.
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In a few reported cases, overdose with calcium channel blockers that was initially refractory to atropine became more responsive to this treatment when the patients received large doses (close to 1 gram/hour for more than 24 hours) of calcium chloride.
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Clean intermittent catheterization is catheterization performed by the patient or caregiver on a periodic basis to empty the bladder.
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As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with ofloxacin.
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The following GERD-associated complications are serious and require immediate medical attention: Esophageal stricture: This is a narrowing of the esophagus that makes it hard to swallow foods or liquids.
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Thus, concomitant therapy with warfarin and etodolac should not require dosage adjustment of either drug.
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Following either intravenous or oral administration of 14C-labeled telmisartan, most of the administered dose (>97%) was eliminated unchanged in feces via biliary excretion; only minute amounts were found in the urine (0.91% and 0.49% of total radioactivity, respectively).
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A schistocyte is a red blood cell undergoing fragmentation, or a fragmented part of a red blood cell.
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You will also continue with your glaucoma medicine.

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True gynecomastia refers to enlarged glandular tissue rather than fat (adipose) tissue.
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The agent usually found in over-the-counter cough suppressants is dextromethorphan (Benylin, Pertussin CS or DM, Robitussin Maximum Strength, Vicks 44 Cough Relief).
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A second dose of AMERGE Tablets or other medication was allowed 4 to 24В hours after the initial treatment for recurrent headache.
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Amoxicillin is, however, susceptible to degradation by ОІ-lactamases and, therefore, the spectrum of activity does not include organisms which produce these enzymes.
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A physical therapist will help with gentle, range-of-motion exercises and strenthening exercises.
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Orlistat may have interfered with the absorption of vitamin K, which normally inhibits warfarin.
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Human studies for up to one year have not detected any clinically significant effects on the endocrine system.
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On a mg/m2 basis, corrected for the 3% oral bioavailability, the "no adverse effect dose" (5 mg/kg/day given orally) was approximately the same as the maximum recommended human dose (MRHD); the teratogenic dose (20 mg/kg/day given orally) was about four times the MRHD on a mg/m2 basis, or 16 times the MRHD on a mg/kg basis.

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Since cross reactivity, including bronchospasm, between aspirin and other nonsteroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, MOTRIN Suspension should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.
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This can happen to older children with severe damage to the nervous system, children with a life-threatening bacterial infection in the blood (sepsis), and children with a weakened immune system.
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The frozen parts are thawed until they are pink, which shows that the circulation has returned.
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Most episodes of bleeding remain undetected at the time they occur because they are not severe enough to cause significant neurological damage.
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Sometimes a patient may need a specific type of care that cannot be provided at home or the primary caregiver is too frail or ill to provide care.
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Quinidine: In a small number of patients with hypertrophic cardiomyopathy (IHSS), concomitant use of verapamil and quinidine resulted in significant hypotension.

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Levulan received FDA approval on December 3, 1999. It is manufactured by Guidelines, Incorporated under the brand name LevulanВ® Kerastick, a 20% topical solution.
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Renal dysfunction does not affect lidocaine kinetics but may increase the accumulation of metabolites.
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Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including VIDEX.
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Internal bleeding is the most common serious complication of splenoportography.
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Ill people may also have fatigue, chills, headache, or body aches.
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V. vulnificus can cause disease in those who eat contaminated seafood or have an open wound that is exposed to seawater.
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When daily doses of sulfasalazine 2 g and weekly doses of methotrexate 7.5 mg were coadministered to 15 rheumatoid arthritis patients in a drug-drug interaction study, the pharmacokinetic disposition of the drugs was not altered.

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Observational studies have found that lens clarity, which is used to diagnose cataracts, was better in regular users of vitamin E supplements and in persons with higher blood levels of vitamin E. A study of middle-aged male smokers, however, did not demonstrate any effect from vitamin E supplements on the incidence of cataract formation.
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The ice pack should be removed when the skin is completely numb or if you sense a burning or pins-and-needles feeling.
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Its molecular formula is C51H79NO13 and its molecular weight is 914.2. TheВ structural formula of sirolimus is shown below.
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Also, new NSAIDs with mechanisms of action that are different from current drugs are on the horizon.
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Gradually incorporating a regular chondromalacia patella exercise routine will expedite rehabilitation.
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The quadriceps femoris muscle group straightens the leg at the knee.
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Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats.

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When complete heart block occurs, special areas in the ventricles may create electrical signals to cause the ventricles to contract.
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ZOLOFT was statistically significantly more effective than placebo as measured by the LSAS and the percentage of responders.
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The three most common vaginal infections are bacterial vaginosis (BV), Candida vaginitis (yeast infection) and Trichomonas vaginitis.
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Efficacy assessment was based on quality of the radiographic diagnostic visualization (i.e., either excellent, good, poor, or none) and on the ability to make a diagnosis (i.e., either confirmed a previous diagnosis, found normal, or diagnosed new findings).
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DNA gyrase helps replicate and repair DNA, and topoisomerase IV helps bacterial cells replicate.
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The current model to explain addiction suggests that addiction begins with the basic pleasure and reward circuits in the brain, which involve the chemical dopamine.

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As a general principle, no drug should be taken during pregnancy unless it is clearly necessary.
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Infected raccoons have been found throughout the United States, mainly in the Midwest, Northeast, middle Atlantic, and West coast.
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Down syndrome (also referred to as Down's syndrome or trisomy 21) is a genetic disorder caused by having an extra 21st chromosome.
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The increase with the tablet (~30%) is significantly greater than with the capsule (~10%). Consequently when each is administered with food, the amount absorbed from the capsule is about 80% of the amount absorbed from the tablet (See [#section-3.2.3 Figure 1]). Administration of the capsule contents sprinkled on applesauce is not bioequivalent to administration of an intact capsule under fasting conditions.
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Many risk factors make this occurrence more likely, such as smoking, exposure to certain chemicals, and diet.
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Cholera is an acute and potentially severe gastrointestinal disease (stomach and intestines) caused by the bacteria Vibrio cholerae.
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Elbow injuries that damage nerves and blood vessels often need to be fixed in the operating room.
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This resistance is lost when the antibiotic is removed.
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ISOVUE (lopamidol Injection) is hypertonic as compared to plasma and cerebrospinal fluid (approximately 285 and 301 mOsm/kg water, respectively).

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Yeast infections may be treated using over-the-counter medications, but other causes of vaginal discharge require prescription medications.
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In an aqueous environment, such as the gastrointestinal tract, the drug overcoat dissolves within one hour, providing an initial dose of methylphenidate.
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This simple test records your heart's electrical activity.
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However, a single measurement of an elevated blood GH level is not enough to diagnose acromegaly: Because GH is secreted by the pituitary in impulses, or spurts, its concentration in the blood can vary widely from minute to minute.
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Some people use canes to take pressure off painful joints.
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Research has found that people with high cholesterol and high blood pressure were six times as likely to develop Alzheimer's disease as those without elevated blood pressure and high cholesterol levels.
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The timing of decompressive hemicraniectomy and indications remain unclear.
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The usual locations for the bacteria to enter your body are puncture wounds, such as those caused by rusty nails, splinters, or insect bites.
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Laboratory tests are not ordinarily required in otherwise healthy patients.

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Thyroid is not associated with serious adverse reactions and does not have a known tumorigenic potential.
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Insomnia is not defined by the number of hours of sleep a person gets or how long it takes to fall asleep.
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Another form of manipulation was developed in 1895 by David Daniel Palmer, a local magnetic healer, and a student of Dr Still's. Palmer termed his healing art "chiropractic," from the Greek words chiro and praktikos, meaning "done by hand.
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Epo is produced in the kidneys in adults, and in liver cells in the fetus.
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Different types of treatment are available for patients with breast cancer.
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If the patient has severe colitis or does not respond to mesalamine preparations, they may be treated with corticosteroids.
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This offers a metabolic explanation for the low systemic activity of oral flunisolide itself since the metabolite has the low corticosteroid potency (on the order of the Cortisol standard).
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The major circulating metabolite is noroxycodone, which possesses weak analgesic activity.
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Once the cause is determined, treatment can be started to prevent further episodes.

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It occurs when specific nerve cells in the cerebral cortex (the thin layer of cells covering the brain which is responsible for most higher level mental functions) that control voluntary movement gradually degenerate, causing the muscles under their control to weaken.
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A scout film should be made routinely before the contrast medium is injected.
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IN THIS ARTICLEIntroduction: History of Food and Drug RegulationFDA Mission and BackgroundProduct Approvals (Drugs and Food)Food LabelsFood SafetyDietary Supplements, Infant Formulas, CosmeticsEnforcement of the FD&C ActFDA ChallengesFor More InformationSynonyms and KeywordsAuthors and EditorsFood SafetyEven before recent bioterrorism, public health experts were concerned about the safety of the food supply and the large amount of food poisoning cases that occur each year.
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Antibiotics are usually recommended for a squeeze involving the frontal sinuses.
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The primary theory is that the body is triggered to attack itself in response to infection of some type.
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You should have regular breast examinations by a health-care professional and examine your own breasts monthly.
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Caution should be used when administering VAPRISOL to patients with renal impairment.
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Therefore, SorineВ® (Sotalol HCl) Tablets should be used during pregnancy only if the potential benefit outweighs the potential risk.
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Authors and EditorsAuthor: Samuel M Keim, MD, Program Director, Associate Professor, Department of Surgery, Division of Emergency Medicine, University of Arizona Health Sciences Center.

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And a person may be contagious for 24 hours before any symptoms occur.
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The plasma elimination half-life ranges from 1 to 4 hours for acetaminophen, and from 2.5 to 3 hours for codeine.
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These increases were almost always reversible upon discontinuation of enalapril or enalaprilat and/or diuretic therapy.
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Routine blood tests such as a complete blood count (CBC) may provide information about possible infection,anemia, or vitamin deficiency.
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This is because flumazenil injection has not been established in patients as an effective treatment for hypoventilation due to benzodiazepine administration.
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In adults in the United States such injuries commonly result from motor vehicle accidents, assaults, and falls.
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Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
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Penetrating trauma may cause immediate, severe symptoms or only minor symptoms despite a potentially life-threatening injury.

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The normal values may differ slightly based on the reference range and the machine used in the laboratory and, therefore, the results may be slightly different from one laboratory to the next.
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A number of different gene mutations have been shown to cause MODY, all of which limit the ability of the pancreas to produce insulin.
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The initial dose of Prograf should be administered no sooner than 6 hours after transplantation.
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This is usually referred to as paroxysmal supraventricular tachycardia (often abbreviated PSVT).
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Additionally, the amount of blood in the body increases which can also cause blood vessles to expand.
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Patients had received daily ACTONEL (2.5 mg or 5 mg) or placebo for 2 to 3 years.
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Contraction stress testing (CST), a non-stress test (NST), or biophysical profiling (BPP) may be appropriate, depending upon the week of pregnancy.
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Although not studied, an interaction of topiramate and valproic acid may exacerbate existing defects or unmask deficiencies in susceptible persons.