Repligen Receives Orphan Drug Designation From The FDA For RG1068 For MRI Imaging Of The Pancreas

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Signs andSymptoms: Serious overdose with codeine is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension.

Most eye problems are treated with oral antibiotics.

No signs of acute cardiac toxicity were observed.

Most adverse effects are mild, but 21% of patients discontinued therapy because of an adverse event, principally diarrhea, rash, nausea, vomiting, GI pain and neutropenia.

For example, a parent who has a congenital heart defect is slightly more likely than other people to have a child with the problem.

Eclampsia and HELLP syndrome will be mentioned separately in the text.

In postmenopausal women with documented heart disease (n = 2,763, average age 66.7 years) a controlled clinical trial of secondary prevention of cardiovascular disease (Heart and Estrogen/Progestin Replacement Study; HERS), treatment with CE/MPA (0.625 mg/2.5 mg per day) demonstrated no cardiovascular benefit.

Studies indicate that a toxin produced by Clostridium difficile is a primary cause of “antibiotic­associated” colitis.

In most people with primary Raynaud's, the disorder is successfully managed with lifestyle adjustments.

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Whole or crushed flaxseed can be mixed with water or juice and taken by mouth.
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But some meditative traditions, such as yoga or tantra, are common to several religions or occur outside religious contexts.
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The pharmacokinetics of montelukast are nearly linear for oral doses up to 50 mg.
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No such effects were noted at 5 mcg/kg (less than the maximum recommended human daily inhalation dose in adults on a mcg/m2 basis).
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The antihypertensive effect of quinapril continues during long-term therapy, with no evidence of loss of effectiveness.
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If the individual appears to be in distress, the emergency medical system should be activated (call 911 if available).
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Upon in vitro incubation, one of the minor metabolites formed is 6ОІ-hydroxy-mometasone furoate.
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The better control a patient has of the disease, the fewer problems they will have in the long run.
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People making decisions about genetic testing should be aware that when test results are placed in their medical records, the results might not be kept private.

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This category also provides a buffer zone, which prevents small uncontrolled technical factors from causing major discrepancies in interpretation.
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This prevents major bleeding from the site.
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Possible problems with implants include mechanical breakdown and infection, although mechanical problems have diminished in recent years because of technological advances.
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ATROVENT Nasal Spray 0.06% is a metered-dose, manual pump spray unit which delivers 42 mcg ipratropium bromide (on an anhydrous basis) per spray (70ВµL) in an isotonic, aqueous solution with pH adjusted to 4.7. It also contains benzalkonium chloride, edetate disodium, sodium chloride, sodium hydroxide, hydrochloric acid, and purified water.
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The usual duration of therapy is 7 to 14 days.
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Because of the potential for serious adverse reactions from ofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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In clinical studies in hypertensive patients with unilateral or bilateral renal artery stenosis, increases in blood urea nitrogen and serum creatinine were observed in 20% of patients treated with enalapril.
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Bleeding time is usually unaffected by heparin.

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Some cardiomyopathies are completely preventable, for example alcoholic cardiomyopathy due to long-term excessive alcohol consumption.
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MICARDIS HCT (telmisartan/hydrochlorothiazide) has been evaluated for safety in over 1700 patients, including 716 treated for over six months and 420 for over one year.
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It forms a pronounced bulge at the surface of the ovary called the blister.
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You will be started on a low dose of FORTAMETВ® and your dosage will be increased gradually until your blood sugar is controlled.
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During insulin withdrawal, patients should test their urine for glucose and acetone at least three times daily and report results to their physician.
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Transplant patients already on this drug should not discontinue on becoming pregnant.
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RYR1 mutations are also associated with an increased risk of malignant hyperthermia.
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Cigarette smoking increases the risk of serious adverse effects on the heart and blood vessels from the use of birth control pills.

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Non alcohol related causes can include AIDS, cancer, renal (kidney) dialysis, and hyperthyroidism (thyrotoxicosis).
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When the stump dries out, usually between 1-4 weeks after birth, and the wound heals, usually within a few more days, you will be able to give your baby a tub bath.
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A doctor can recommend resources for a professional home-safety consultant visit.
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Although the crash scenario often dictates the area of the body injured, fatal crashes are most often a result of traumatic brain injury.
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Alcohol (ethanol) can decrease the intensity of the tremors.
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All lost weight and body fat, but those taking the calcium supplements lost significantly more than subjects eating the unsupplemented standard diet, and those on the high-dairy diet lost by far the most.
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Stem cells (immature blood cells) are removed from the blood or bone marrow of the patient or a donor and are frozen and stored.
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A blow to the knee or a fall is often the cause; sudden twisting can also result in a sprain (see fig.

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IN THIS ARTICLEWhat is cholesterol?What causes high cholesterol?What are the symptoms of high cholesterol?How often should I have my cholesterol checked?How is cholesterol checked?Should I only be concerned with my total cholesterol number?What kinds of problems are caused by high cholesterol?What can I do to prevent high cholesterol?When would a doctor prescribe a medication to lower cholesterol?What are the uncontrollable and controllable risk factors for high cholesterol?For More InformationWeb LinksSynonyms and KeywordsAuthors and EditorsWhat are the symptoms of high cholesterol?High cholesterol doesn’t have any symptoms.
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Patients should also be encouraged to read the NSAID Medication Guide that accompanies each prescription dispensed.
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It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.
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Swelling of a lymph node located deep inside the body may have different consequences from swelling of those just under the skin.
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Estrogen is known to play a role in regulation of bone growth.
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Crohn's disease is not an approved indication for Flagyl ER 750 mg tablets.
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The safety and efficacy of lomefloxacin in the treatment of acute bacterial exacerbation of chronic bronchitis due to S pneumoniae have not been demonstrated.
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An audiologist gives tests that determine the softest sounds and words a person can hear and other tests that determine the ability to recognize sounds in words and sentences.

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Histamine is one of the better-known mediators produced by the body.
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Intracellularly lamivudine is phosphorylated to its active 5′-triphosphate metabolite, lamivudine triphosphate (3TC-TP).
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Typical symptoms of mania include pressure of speech, motor hyperactivity, reduced need for sleep, flight of ideas, grandiosity, elation, poor judgment, aggressiveness, and possibly hostility.
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Also, tell your physician if you have been outdoors (camping, hiking, etc.
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Eventually everyone within close contact with the infected individual will become infected and develop symptoms.
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Remember RICE! Rest the injured part.
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If you miss any periods (no bleeding on the days that you take yellow pills), you must consider the possibility that you may be pregnant.
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Growth plate injuries can be caused by an event such as a fall or blow to the limb, or they can result from overuse.
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McDonald said, the attacks proved that medical professionals should be the primary source of health care information, as lay authorities broadcast confusing and inaccurate messages.

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If different types of vaccine are used for the first and second doses, however, there is no need to revaccinate a child.
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This increases the pressure in the mouth and throat and pushes the Eustachian tubes open.
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Changes in normal, healthy bacteria in the gastrointestinal tract from the use of antibiotics or recent gastrointestinal surgery can also lead to an increased risk of infection.
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Interviewing parents and the patient along with contact with the patient's teacher(s) is crucial.
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If indicated, there are some implanted devices that are both pacemakers and defibrillators.
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For some patients, the doctor may recommend an eye examination to check for uveitis (inflammation of part of the eye), which sometimes occurs with vitiligo.
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Some studies with human insulin have shown increased circulating levels of insulin in patients with hepatic failure.
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Antihistamines appear to be metabolized in the liver chiefly via mono- and didemethylation and glucuronide conjugation.

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Study T20-204 was an open-label, multicenter trial that evaluated the safety and antiviral activity of FUZEON in treatment-experienced pediatric subjects.
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This dose is approximately 30 times and 4 times the maximum recommended human dose of METADATE CD on a mg/kg and mg/m2 basis, respectively.
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Carefully consider the potential benefits and risks of PREVACID NapraPAC and other treatment options before deciding to use PREVACID NapraPAC.
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From the kidneys, urine travels down two thin tubes called ureters to the bladder.
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Previous PageGlossary Printer-Friendly Format |  Email to a Friend Privacy Policy Diabetes Find tips and advances in treatment.

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Warn that visual symptoms may render such activities as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting (see WARNINGS).
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The nostrils lead into the nasopharynx.
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Family history is often important, especially if there is concern about sudden cardiac death at an early age.
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CYP2D6 Substrates:В Caution should be taken when ENABLEX is used concomitantly with medications that are predominantly metabolized by CYP2D6 and which have a narrow therapeutic window, such as flecainide, thioridazine and tricyclic antidepressants (see PRECAUTIONS, Drug Interactions).
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Figure 2 shows the percentage of Seasonique™ subjects participating in trial PSE-301 with ≥ 7 days or ≥ 20 days of intermenstrual bleeding or spotting during each treatment cycle.
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Robinul (glycopyrrolate) tablets are contraindicated in those patients with a hypersensitivity to glycopyrrolate.
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Facial fracture refers to any injury that results in a broken bone or bones of the face.
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Slow electrical conduction could lead to abnormal heart beats.

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Trauma to the foot: Any trauma to the foot can increase the risk for a more serious problem to develop.
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All calcium tablets should be taken at a different time of day than your ACTONEL tablet.
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The poisoning can be unintentional.
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Similarly, in the rat there was no evidence of teratogenicity; however, a decrease in fetal weight was observed with the high–dose combination.
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If exposed, therapy with varicella-zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG), as appropriate, may be indicated.
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This symptom is an important milestone, because it is not easy to treat and a common source of disability in late disease.
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A 54-year-old man became semicomatose three days after taking kava with alprazolam (Xanax).
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Any unstable medical conditions or infections must be treated before surgery.
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They may be used alone or to carry drugs, toxins, or radioactive material directly to cancer cells.

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In over 1,000 patients treated with NEXIUM (10, 20 or 40 mg/day) up to 6-12 months, the prevalence of ECL cell hyperplasia increased with time and dose.
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Mast cell inhibitors are available as nasal sprays to prevent runny nose or eye drops for itchy eyes.
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The delay in maximum contrast enhancement can range from five to forty minutes, depending on the peak iodine levels achieved and the cell type of the lesion.
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There are no well-controlled human studies of the use of FORADIL AEROLIZER in nursing mothers.
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The effect of food on spironolactone absorption (two 100 mg spironolactone tablets) was assessed in a single dose study of 9 healthy, drug-free volunteers.
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The typical symptom is stiffness of the lower back in the morning, but not everyone has this.
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In many of the reported cases, treatment with protease inhibitors was continued or restarted.
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The term "benign essential tremor" has been used in reference to this tremor; however, this is misleading since the tremor can be very severe and disabling.
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This option is available to people whose nausea and vomiting do not improve with medications.

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Using energy in our bodies often has damaging side effects on cells, and certain food elements such as vitamin C have been seen to be vital in protecting against the aging effect of this oxidizing damage.
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Do Kegel exercises to strengthen your pelvic muscles.
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CORTROSYNв„ў can be injected intravenously in 2 to 5 mL of saline over a 2-minute period.
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Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system.
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Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations, unless the theophylline dose is appropriately increased.
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The antidote, N-acetylcysteine, should be administered as early as possible, and within 16 hours of the overdose ingestion for optimal results.
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A less intrusive type of electrical stimulation is available that magnetically stimulates the pudendal nerve from outside the body.
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Staging is the process used to find out how far the cancer has spread.
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When there is enough blood to be visible, the urine may look pinkish, red, or smoky brown (like tea or cola).

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Before the tumescent method or suction, the laser-assisted liposuction portion may be used to help melt the fat and seems to result in larger amounts of fat being suctioned, with potentially more retraction of the areas as well.
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Menstrual blood has not been shown to increase the risk of shark attack, but a shark in the vicinity can likely sense the blood.
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A true low-salt syndrome may rarely develop with spironolactone and hydrochlorothiazide therapy and may be manifested by increasing mental confusion similar to that observed with hepatic coma.
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There are many possible causes of nontraumatic ICH, and 1 risk factors usually can be identified if a complete evaluation is done.
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Usual adult dosage is 50 mg promethazine with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid.
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The final visual result may not be known for up to several months following surgery.
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Tacrolimus has an empirical formula of C44H69NO12•H2O and a formula weight of 822.03. Tacrolimus appears as white crystals or crystalline powder.
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Patient wait times for specialist appointments are growing almost as fast as specialist recruiting incentives.
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The shaft is the long, slender portion of the bone.

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An infestation may still be present even if a skin scraping or biopsy is negative.
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A familial tremor is usually a relatively benign condition, affecting movement or voice quality but seldom having any other effects.
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Pericarditis associated with tuberculosis, pus-producing bacterial infections, and cancer usually have a more guarded prognosis.
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Although domestic violence usually includes violent attacks, it is not limited to physical acts of violence, but may include psychological, economic, and sexual abuse as well as attempts to isolate the partner.
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Constrictive pericarditis occurs when the pericardium scars down and adheres to the heart surface; it can prevent the heart from expanding to receive blood returning from the body.
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Researchers have determined, however, that a particular version of the HLA-B gene (called HLA-B27) increases the risk of developing this disorder.
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This accumulation can result from CSF overproduction, obstruction of CSF flow within the brain, or a reduction in the absorption of CSF into tissues.
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At 38 weeks (50 weeks total), a statistically significantly lower relapse rate (defined as symptoms sufficient to meet a diagnosis of major depressive disorder for 2 weeks or a modified HAMD-17 score of ≥ 14 for 3 weeks) was observed for patients taking fluoxetine compared to those on placebo.
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In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation.