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Results of various mutagenicity studies (Ames test, mouse dominant lethal test, mouse micronucleus test, and chromosome aberration of bone marrow in Chinese hamsters) were negative.
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This phenomenon, which may be due to progression of the underlying disease or to diminished responsiveness to the drug, is known as secondary failure, to distinguish it from primary failure in which the drug is ineffective during initial therapy.
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Myocardial degeneration was found in mice and rats following administration of abacavir for 2В years.
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The two main proteins are hemagglutinin (H) and neuraminidase (N).
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NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients.
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IN THIS ARTICLEThe Bends OverviewThe Bends CausesThe Bends SymptomsWhen to Seek Medical CareThe Bends TreatmentSelf-Care at HomeMedical TreatmentNext StepsFollow-upPreventionOutlookMultimediaSynonyms and KeywordsAuthors and EditorsNext StepsFollow-upFollow up immediately for any further signs or symptoms of decompression illness within the next 7 days.

For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 9:00 a.m. to 4:30 p.m. Deaf and hard-of-hearing callers with TTY equipment may call 1-800-332-8615. The call is free and a trained Cancer Information Specialist is available to answer your questions.
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The health care practitioner will gather the appropriate information to help make the correct diagnosis.

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The aortic valve closes quickly to prevent blood from flowing back into the left ventricle, which is already filling up with freshly-oxygenated blood.
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Diagnosing scleroderma is easiest when a person has typical symptoms and rapid skin thickening.
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The medication may shorten the course of the illness or lessen the symptoms.

The possibility of prolonged or secondary apnea should be considered if tobramycin is administered to anesthetized patients who are also receiving neuromuscular blocking agents, such as succinyl-choline, tubocurarine, or decamethonium, or to patients receiving massive transfusions of citrated blood.
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Mutations in the MEN1 gene cause multiple endocrine neoplasia type 1. This gene provides instructions for producing a protein called menin.
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The pericardium holds the heart in its appropriate position in the chest and protects it from infection or tumors that might spread directly from other organs near the heart, such as the lung or esophagus.

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Sterile tobramycin sulfate is supplied as a dry powder.
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Conversely, when these drugs are withdrawn, the patient should be observed closely for loss of glycemic control.
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Amitriptyline/Nortriptyline — Administration of a single oral 50 mg dose of amitriptyline to 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline.
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The overdose ranged from slightly above the recommended pediatric dosage to a dose exceeding 19 g/kg.

Cryoglobulins cause a wide array of symptoms, including Raynaud phenomenon.
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Furthermore, the effect of added progestins on this putative benefit is not yet known.
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The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered.

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Central Nervous System: Lightheadedness; mental depression manifested by insomnia, lassitude, weakness, fatigue; reversible mental depression progressing to catatonia; visual disturbances; hallucinations, vivid dreams, an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics.
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Low estrogen levels in young women put these women at risk for osteoporosis and heart disease.
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Rubramin PC (Cyanocobalamin Injection) contains cyanocobalamin (vitamin B12) in a clear, red, sterile, nonpyrogenic, aqueous solution in a potency of 1000 mcg/mL (cobalt: 40 mcg/mL) for intramuscular use.

In no case should there be more than 7 consecutive patch-free days.
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Scar tissue resulting from the healing process may also lead to a narrowed bowel, and strictures are often present.
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There are several types of cancer that start in the skin.

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However, since the serum concentrations of these steroids were not determined, their incomplete absorption and/or first-pass metabolism could not be ruled out as a reason for their reduced in vivo activities.
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Rituximab is beneficial in the treatment of both lymphoma and rheumatoid arthritis.
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He hung on courageously for seven more years, running and competing up until the end of his life.
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Use of wheelchairs, braces, and other mobility aids is common, particularly (although not exclusively) among people with more severe types of OI.

It is important to also notify any sex partners so they can be tested for syphilis and treated if necessary.
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The goal of suppressive therapy is to inhibit growth and/or function of abnormal thyroid tissue.
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The same situation exists with too much fluid inside the eye—the more fluid, the higher the pressure.

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This should be done periodically by the teacher and family, but also by a formal review by the school special education team at least annually.
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See [#section-4 CLINICAL PHARMACOLOGY].) The use of dosing formulae, as compared to empirical dose calculation based on body surface area, allows compensation for patient variations in pretreatment renal function that might otherwise result in either underdosing (in patients with above average renal function) or overdosing (in patients with impaired renal function).
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In 2006, the Centers for Disease Control and Prevention (CDC) reported that a total of 58.8% ofCalifornia adults were overweight or obese (35.5% and 23.3%, respectively).
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The relationship of these symptoms to uncharacterized urinary proteins is uncertain.
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NovoLogВ® Mix 70/30 suspension should be visually inspected and resuspended immediately before use.
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After taking the pills, the patient should also do the following: Get into the habit of carefully washing the hands after using the toilet, and before and after eating.
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Compared to prior experience with clarithromycin monotherapy, the two-drug regimen of clarithromycin and ethambutol was well tolerated and extended the time to microbiologic relapse, largely through suppressing the emergence of clarithromycin resistant strains.
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Examples of TNF inhibitors include etanercept and infliximab.

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Clinically important improvement in symptom control has been found in most studies to require peak serum theophylline concentrations >10 mcg/mL, but patients with mild disease may benefit from lower concentrations.
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Amenorrhea results from decreases in circulating estrogen, which then negatively affects calcium balance.
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Patients with inborn errors of metabolism or reduced hepatic mitochondrial activity may be at an increased risk for hyperammonemia with or without encephalopathy.
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This procedure uses paper disks impregnated with 15-Вµg clarithromycin to test the susceptibility of microorganisms to clarithromycin.
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The geometric mean ratios (FORTAMETВ®/ immediate-release metformin) of AUC0-24hr, AUC0-72hr, and AUC0-inf.

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Also, blood can ooze downward so that bruising may be noted in the back of the knee or in the calf.
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The pre-study inhaled corticosteroid requirements were reduced by approximately 37% during a 5- to 7-week placebo run-in period designed to titrate patients toward their lowest effective inhaled corticosteroid dose.
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The use of sirolimus in combination with cyclosporine or tacrolimus was associated with an increase in HAT (hepatic artery thrombosis or "clotting of the artery feeding the liver"); most cases of HAT occurred within one month post-transplant and most led to graft loss or death.
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Other names for ADC are HIV-associated dementia and HIV/AIDS encephalopathy.
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There is (1) Olympic lifting (where athletes lift the weight overhead like you see in the Olympics), (2) power lifting (a competition where athletes perform the squat, dead lift, and bench press), and (3) weight lifting (a sport where athletes lift heavy weights—typically fewer than six reps).
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Even simple measures such as taking the stairs instead of the elevator and short walks eventually add up to a lot of calories burned.

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They may grow as a single tumor or in clusters.
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The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
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Dosage should be initiated at a lower level and increased according to tolerance and clinical response to a usual maximum of 100 mg daily.

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Pantoprazole is provided in a delayed-release, or extended-release form, which allows once daily administration.
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Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you.
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Her blood sugars have been well controlled in the 90-130 range without hypoglycemic episodes.
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In the treatment of well-differentiated (papillary and follicular) thyroid cancer, levothyroxine is used as an adjunct to surgery and radioiodine therapy.
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In rare instances, initial doses of 100 mg a day may be warranted in patients who have an increased response to verapamil [e.g. patients with impaired renal function (See [#section-8 PRECAUTIONS]), impaired hepatic function, elderly, small people, etc.
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Without them, your intestines cannot absorb fats and proteins fully.
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Depending on the patient's response, the dosage can be decreased to 2.5 mg or increased to 10 mg once a day.
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Three patients who received Carac and nine patients who received EfudexВ® 5% Cream had measurable plasma fluorouracil levels; however, only one patient receiving Carac and six patients receiving EfudexВ® 5% Cream had a sufficient number of data points to calculate mean pharmacokinetic parameters.
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After each watery stool, the person should attempt to take in fluid roughly equal to the amount excreted (about 1-3 ounces for children under age 2, 3-8 ounces for older children, and 8 or more ounces in adults).

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Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals.
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Ketoacidosis or diabetic coma is a medical emergency.
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Do not puncture.
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Plus disease" means that the blood vessels of the retina have become enlarged and twisted, indicating a worsening of the disease.
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This occurs when the blood in the hemorrhoid clots.
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Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced (see DOSAGE ANDADMINISTRATION and OVERDOSAGE).
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Side effects occurring in fewer than 5% of women include acne or other skin problems, back pain, breast tenderness, headache, mood changes, and nausea.
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This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
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Losartan is an orally active agent that undergoes substantial first-pass metabolism by cytochrome P450 enzymes.

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Persistent hyperkalemia may require dialysis.
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Overuse of the shoulder can lead to more rapid age-related deterioration.
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Controlled clinical trials have failed to show that clear benefit is associated with the administration of a second 6-mg dose in patients who have failed to respond to a first injection.
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Old condoms can become dry and break more easily.
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This drug should not be used after the expiration date stated on the container label.
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Once the egg has been fertilised by a single sperm, no more sperm can enter.
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Therefore, interactions may occur with other drugs that are also metabolized by the liver.
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Media type: PhotoMedia file 6: Irritation (redness) of the eye caused by a poorly fitting soft contact lens.
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Allergens are substances from foods, plants, animals, or the air that inflame the skin because the immune system overreacts to the substance.

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The mite causes itch and skin irritation in humans, but it dies in a few days, before it can reproduce.
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Older children can be taught to select healthy, nutritious foods and to develop good exercise habits.
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Exclusions from this trial included, among others, patients with uncontrolled hypertension, need for cardiac surgery, history of CABG within 3 months of index event, severe or symptomatic bradycardia, non-atherosclerotic cause of angina, clinically significant renal impairment (creatinine > 2.5 mg/dL), and clinically significant hepatic dysfunction.
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They're often used to treat less dangerous heart rhythms, such as those that occur in the upper chambers of the heart.
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Aside from heart attacks, pulmonary embolus (blood clot in the lung) and aortic dissection or tear can be fatal causes of chest pain.
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People with gangrene require urgent assessment and treatment to prevent the spread of gangrene.
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Epinephrine and other appropriate measures should be available for treatment of serious allergic events such as anaphylaxis.
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Many people will have microscopic blood in urine, not visible with the naked eye.

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Symptoms of a drug interaction between an SSRI and an MAOI include: hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, mental status changes that include confusion, irritability, and extreme agitation progressing to delirium and coma.
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Eventually, bacteria present in the large intestine (colon) begin to digest (ferment) the lactose molecule by utilizing their own lactase enzyme, producing hydrogen gas and smaller molecules as byproducts.
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In patients with renal disease or congestive heart failure, therapy resulting in central volume expansion is not without hazard.
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Some experiments in cell cultures have shown that cat’s claw protects against nerve cell death.
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Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
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IN THIS ARTICLEDementia in ALS OverviewDementia in ALS CausesDementia in ALS SymptomsWhen to Seek Medical CareExams and TestsDementia in ALS TreatmentMedicationsNext StepsFollow-upPreventionOutlookSupport Groups and CounselingFor More InformationWeb LinksSynonyms and KeywordsAuthors and EditorsDementia in ALS CausesWe do not know what causes frontal lobe dementia in people with ALS.
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There have been reports of respiratory and cardiovascular collapse in patients who received therapeutic doses of diazepam and Buprenex.
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Most often the abnormal tremor is observed in the distal parts of the limbs (hands, fingers); however, every part of the body (such as the head, the tongue, the vocal cords, or the trunk) can be affected by the tremor.
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Some patients respond satisfactorily on 50 to 75 mg daily.

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They do develop heparin-induced platelet antibodies, but without associated thrombocytopenia.
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The affected person usually needs to support the elbow of the affected arm in the opposite hand to ease the tension on the shoulder and upper arm.
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The combined time (vial and infusion bag) at room temperature should not exceed 12 hours; the combined time (vial and infusion bag) under refrigeration should not exceed 48 hours.
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If Hirschsprung disease is seriously considered as a cause of your child’s encopresis, a biopsy of the rectum may be necessary.
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Echocardiograms and ultrasounds can be used to assess heart function including valve anatomy, ejection fraction, and function of the contraction of the atrium and ventricle walls.
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Special Senses: Bilateral ocular irritation, lacrimation, itching, conjunctival chemosis, infection, and conjunctivitis.
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IN THIS ARTICLEMigraine Headache OverviewMigraine Headache CausesMigraine Headache SymptomsWhen to Seek Medical CareExams and TestsMigraine Headache TreatmentSelf-Care at HomeMedical TreatmentOther TherapyNext StepsFollow-upPreventionOutlookFor More InformationWeb LinksMultimediaSynonyms and KeywordsAuthors and EditorsPictures of Headache & Migraine Triggers - Slideshow Viewer Comments: Migraine Headache - Effective TreatmentsOutlookAfter the headaches are under control, the prognosis is very good.
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