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quinine information:
Because malaria is life-threatening, the risks associated with quinine use are justified for that condition. Quinine needs to be dosed carefully, and FDA-approved labeling reflects the fact that the risks associated with the use of this drug for treatment of leg cramps outweigh the benefits. 6 mg/L and the ratio of cord plasma to maternal plasma quinine levels averaged 0. If you are or will be breast-feeding while you use Quinine Capsules, check with your doctor. Unlike the approved product, many unapproved quinine drug products are marketed without labeling cautioning against use of the product for treatment of leg cramps. Quinine was used starting in the 17th century as a prophylactic against malaria. There is also the potential for serious interactions between quinine drugs and other drugs, and there are conditions under which quinine should not be used. In 8 women who delivered live infants 1 to 6 days after starting quinine therapy, placental cord plasma quinine levels were between 1. The FDA-approved labeling for the product provides extensive warnings regarding serious adverse events associated with use of quinine, potentially serious interactions with other drugs, and conditions under which quinine should not be used. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, quinine, quinidine, MAOIs, ginseng); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs).

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